CAS:918830-94-1|6-Aminoadamantane-1,3-diol

Catalogue Number:A580150
Chemical Name:6-Aminoadamantane-1,3-diol
Synonyms:(1s,3s,5R,7S)-6-Aminoadamantane-1,3-diol;6-Aminotricyclo[3.3.1.13,7]decane-1,3-diol
Impurity:Vildagliptin Impurity:CAS Number:918830-94-1
Molecular Formula:C₁₀H₁₇NO₂
Molecular Weight:183.25
Category:Building Blocks; Miscellaneous; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:6-Aminoadamantane-1,3-diol is an intermediate in the preparation of adamantamine inhibitors, which are used in the therapeutic treatment of diseases associated with hydroxysteroid dehydrogenase type 1 (11β-​HSD1), such as diabetes, due to its high specificity over 11β-​HSD2 in mammals. Vildagliptin Impurity.
References:Rohde, J., et. al.: J. Med. Chem., 50, 149 (2007);Claremon, D., et. al.: PCT Int. Appl. 225 pp. Patent (2008) CODEN:PIXXD2;Masuda, K., et. al.: PCT Int. Appl. 380pp. Patent (2008) CODEN:PIXXD2
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