CAS:1224844-38-5|3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Catalogue Number:A602050
Chemical Name:3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms:INK 128; MLN 0128; Sapanisertib
CAS Number:1224844-38-5
Molecular Formula:C₁₅H₁₅N₇O
Appearance:White to Off-White Solid
Melting Point:270-272°C (dec.)
Molecular Weight:309.33
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. TORC1/2 inhibitors are mechanistically distinct from rapamycinand offer a compelling approach to the treatment of cancer by targeting translational control, cell metabolism, growth andangiogenesis.
References:Katayoun, J., et al.: Molec. Cancer. Therap., 8, 1158 (2009);
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