CAS:43197-06-4|N-(Aminocarbonyl)-3-hydroxy-a-methyl-L-tyrosine

Catalogue Number:A602825
Chemical Name:N-(Aminocarbonyl)-3-hydroxy-a-methyl-L-tyrosine
CAS Number:43197-06-4
Molecular Formula:C₁₁H₁₄N₂O₅
Molecular Weight:254.24
Solubility:DMSO
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-(Aminocarbonyl)-3-hydroxy-a-methyl-L-tyrosine is an intermediate used in the synthesis of (S)-(-)-Carbidopa (C178985), which is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
References:Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);
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