CAS:53994-69-7|7-Amino-3-chloro-3-cephem-4-carboxylic Acid

Catalogue Number:A603305
Chemical Name:7-Amino-3-chloro-3-cephem-4-carboxylic Acid
Synonyms:(6R,7R)-7-Amino-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 3-Chloro-7-amino-3-cephem-4-carboxylic Acid; (6R-trans)-7-amino-3-chloro-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-Amino-3-chlorocephalosporanic Acid; Cefaclor EP Impurity E; Cefaclor EP Impurity B
Impurity:Cefaclor EP Impurity B
CAS Number:53994-69-7
Molecular Formula:C₇H₇ClN₂O₃S
Appearance:Pale Yellow Solid
Melting Point:>180°C (dec.)
Molecular Weight:234.66
Storage:-20°C
Solubility:Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
Category:Building Blocks; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Semi-Synthetic;
Applications:7-Amino-3-chloro-3-cephem-4-carboxylic Acid (Cefaclor EP Impurity B) is used as an intermediate in the preparation of semi-synthetic cephalosprin antibiotics (1) such as cefachlor (2).
References:1. Yang, L. et el.: Biotechnol. Lett., 2003 Jul;25(14):1195-8
2. Zhang, Y. et al.: Biocatal. Biotransform., 2007 Jul;59(1):59-64
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