CAS:1194434-39-3|2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Hydrobromide (Anagrelide Impurity B)

Catalogue Number:A604745
Chemical Name:2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Hydrobromide (Anagrelide Impurity B)
Synonyms:USP Anagrelide Related Impurity B Hydrobromide;
Impurity:Anagrelide USP Related Impurity B Hydrobromide
CAS Number:1194434-39-3
Alternate CAS #
free amine: 1159977-03-3
Molecular Formula:C₁₀H₁₀BrCl₂N₃O₂
Appearance:White to Off-White Solid
Melting Point:240-242°C
Molecular Weight:355.02
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Anagrelide impurity B. Quinazolines derivatives are attractive targets because they form an important component of pharmacologically active compounds and are associated with a wide spectrum of biological activities ranging from anticonvulsant and antibacterial to antidiabetic.
References:Molamas, M.S., et al.: J. Med. Chem., 34, 1492 (1991), Brogden, R.N., et al.: Drugs, 47, 809 (1994), Brase, S., et al.: Bioorg. Med. Chem. Lett., 10, 2415 (2002),
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