CAS:16599-33-0|2-Aminoethyl Methanethiosulfonate Hydrobromide

Catalogue Number:A609100
Chemical Name:2-Aminoethyl Methanethiosulfonate Hydrobromide
Synonyms:Methanesulfonothioic Acid S-(2-Aminoethyl) Ester Hydrobromide;
CAS Number:16599-33-0
Alternate CAS #
190852-41-6
Molecular Formula:C₃H₁₀BrNO₂S₂
Appearance:Off-White to Pale Beige Solid
Melting Point:>82°C (dec.)
Molecular Weight:236.15
Storage:4°C
Solubility:Methanol (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Research Tools; Sulfhydryl Active Reagents;
Applications:2-Aminoethyl Methanethiosulfonate Hydrobromide reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor.
References:Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Holmgren, M. et al: Neuropharmacology, 35, 797 (1996) Chahine, M. et al.: Biochemical & Biophysical Res. Commun., 233, 606 (1997), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Rassendren, F., et al.: The EMBO Journal, 16, 3446 (1997), Egan, T.M., et al.: The Journal of Neuroscience, 18(7), 2350 (1998), Lin, C.-W. and Tsung-Yu, C.: J. Gen. Physiol., 116, 535 (2000)
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