CAS:757251-39-1|4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

Catalogue Number:A609725
Chemical Name:4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
Synonyms:4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide;
CAS Number:757251-39-1
Molecular Formula:C₁₃H₁₂FN₃O₂
Appearance:Orange to Very Dark Brown Solid
Melting Point:135 – 137°C
Molecular Weight:261.25
Storage:20°C
Solubility:Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.
References:Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)
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