CAS:1257864-28-0|4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide

Catalogue Number:A609727
Chemical Name:4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide
Synonyms:4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide-d3
CAS Number:1257864-28-0
Alternate CAS #
757251-39-1
Molecular Formula:C₁₃H₉D₃FN₃O₂
Molecular Weight:264.27
Category:Building Blocks; Isotopic Labeled Analogues; Miscellaneous;
Applications:4-(4-Amino-3-fluorophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide is an intermediate for the synthesis of Regorafenib-d3 (R143002), which is the isotope labelled analog of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM and is useful for the treatment of inflammation. Also an anti-proliferative agent.
References:Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)
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