CAS:1243259-19-9|(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide Hydrochloride

Catalogue Number:A612500
Chemical Name:(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide Hydrochloride
Synonyms:[S-(R*,R*)]-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide Dihydrochloride; LM11A 31 Dihydrochloride;
CAS Number:1243259-19-9
Alternate CAS #
102562-74-3-for free base
Molecular Formula:C₁₂H₂₅N₃O₂ • 2HCl
Appearance:White to Off-White Solid
Melting Point:>68°C (dec.)
Molecular Weight:243.35 + 2(36.46)
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Chiral Molecules; Amino Acids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection. This compound has neuroprotective properties.Generally used in Alzheimers Disease, Neuroprotective, Hippocampal neural progenitors. Blood brain barrier (BBB) penetrable, orally bioactive. Blocks p75-medicated cell death.(1) Shows prominent effect against Huntington’s Disease in mice. (2)
References:Simmons DA, et al. 2014. PLoS One. Aug 25;9(8):e102136
Simmons DA, et al. 2016. Hum Mol Genet. Sep 16
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