CAS:765875-58-9|[4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester

Catalogue Number:A617010
Chemical Name:[4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester
Synonyms:Thiazol-5-ylmethyl ((2S,3S,5S)-5-((S)-2-amino-3-methylbutanamido)-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate; Ritonavir EP Impurity D
Impurity:Ritonavir EP Impurity D
CAS Number:765875-58-9
Alternate CAS #
HCl Salt: 165315-97-9
Molecular Formula:C₂₈H₃₆N₄O₄S
Appearance:White to Off-White Solid
Melting Point:145-148ºC
Molecular Weight:524.68
Storage:-20°C
Solubility:Chlorofrom (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:[4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester, is an intermediate that can be used for the synthesis of Ritonavir (R535000), which is a selective HIV protease inhibitor.
References:Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Kempf, D., et al.: J. Med. Chem., 41, 602 (1998),
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