CAS:1294504-67-8|(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol

Catalogue Number:A619483
Chemical Name:(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol
CAS Number:1294504-67-8
Molecular Formula:C₂₉H₃₃N₂O₃F
Appearance:Very Dark Grey Solid
Molecular Weight:476.58
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Very Slightly)
Category:Building Blocks; Chiral Molecules;
Applications:(R)-1-(5-Amino-2-(1-(benzyloxy)-2-methylpropan-2-yl)-6-fluoro-1H-indol-1-yl)-3-(benzyloxy)propan-2-ol is a Tezacaftor (T321510) intermediate. Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.
References:Wu, J., et.al.: Faming Zhuanli Shenqing, 10, (2020);
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