CAS:1184914-03-1|2-Amino-N-(o-tolyl)-thiazole-5-carboxamide

Catalogue Number:A630528
Chemical Name:2-Amino-N-(o-tolyl)-thiazole-5-carboxamide
Synonyms:2-Amino-N-(2-methylphenyl)-5-thiazolecarboxamide
CAS Number:1184914-03-1
Molecular Formula:C₁₁H₁₁N₃OS
Molecular Weight:233.29
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Amino-N-(o-tolyl)-thiazole-5-carboxamide is an impurity of the anti-cancer drug Dasatinib (D193600). Dasatinib is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic.
References:Lombardo, L.J., et al: J. Med. Chem., 47, 6658 (2004); Shah, N. P., et al.: Science, 305, 399 (2004); O’Hare, T., et al.: Curr. Opin. Genet. Dev., 16, 92 (2006)
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