CAL-101-d5

Chemical Name:CAL-101-d5
Synonyms:5-Fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-4(3H)-quinazolinone-d5
Molecular Formula:C₂₂H₁₃D₅FN₇O
Molecular Weight:420.45
Category:Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:CAL-101-d5 is the isotope labelled analog of CAL-101 (C124800); a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs.
References:Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013)
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