Catalogue Number:A637428
Chemical Name:Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
Synonyms:5-(Hydroxymethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile; 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile; Anastrozole EP Impurity E
Impurity:Anastrozole EP Impurity E
CAS Number:120511-88-8
Molecular Formula:C₁₅H₁₈N₂O
Appearance:White to Off-White Solid
Melting Point:156 – 160°C
Molecular Weight:242.32
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.
References:1. Plourde, P. et al.: Breast Cancer Res Treat. 1994;30(1):103-11
2. Buzdar, A. et al.: Cancer. 1997 Feb 15;79(4):730-9.
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CAS:120511-88-8|Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
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