Carfilzomib (2S,4R)-1,2-Hydroxy-O-acetate

Chemical Name:Carfilzomib (2S,4R)-1,2-Hydroxy-O-acetate
Molecular Formula:C₄₂H₆₁N₅O₉
Molecular Weight:779.96
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:Carfilzomib (2S,4R)-1,2-Hydroxy-acetate is an intermediate used in the synthesis of Carfilzomib (2S,4R)-Diol (C183500), which is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References:Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);
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