CAS:13803-65-1|Anhydrotetracycline Hydrochloride

CAS:13803-65-1|Anhydrotetracycline Hydrochloride

Catalogue Number:A656050
Chemical Name:Anhydrotetracycline Hydrochloride
Synonyms:(4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide Hydrochloride;
Impurity:Tetracycline EP Impurity C Hydrochloride
CAS Number:13803-65-1
Alternate CAS #
Free Base: 1665-56-1
Molecular Formula:C₂₂H₂₃ClN₂O₇
Appearance:Light Yellow to Yellow Solid
Melting Point:203-205°C (dec.)
Molecular Weight:462.88
Storage:4°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications:Anhydrotetracycline is a tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems. It is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR systems, binding the Tet(R).
References:Sokoloski, T., et al.: J. Pharm. Sci., 66, 1159 (1977), Paemen, L., et al.: Biochem. Pharmacol., 5, 105 (1996); A. Kamionka, et al.; Nucleic Acids Res. 32, 842 (2004) | M. Resch, et al.; Nucleic Acids Res. 36, 4390 (2008)
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