CAS:114560-48-4|Apaziquone

Catalogue Number:A726110
Chemical Name:Apaziquone
Synonyms:5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione; Apaziquone; EO 9; EO 9 (pharmaceutical); NSC 382456; NSC 382459; (E)-5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-Indole-4,7-dione;
CAS Number:114560-48-4
Molecular Formula:C₁₅H₁₆N₂O₄
Molecular Weight:288.3
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Apaziquone is an indolequinone that is a bioreductive prodrug and a chemical analog of Mitomycin C (M371900), a chemotherapeutic agent. Apaziquone is a potential therapeutic agent for the treatment of non-muscle invasive bladder cancer.
References:Yutkin, V., et al.: Expert. Opin. Investig. Drugs., 21, 251 (2012); Svatek, R.S., et al.: Expert. Rev. Anticancer. Ther., 9, 807 (2009);
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