CAS:2468771-44-8|Apatinib-d8 Hydrochloride

Catalogue Number:A726152
Chemical Name:Apatinib-d8 Hydrochloride
Synonyms:N-[4-(1-Cyanocyclopentyl-d8)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide; YN968D1-d8 Hydrochloride;
CAS Number:2468771-44-8
Alternate CAS #
811803-05-1
Molecular Formula:C₂₄H₁₅D₈N₅O • HCl
Appearance:Off-White to Pale Yellow Solid
Melting Point:>192°C (dec.)
Molecular Weight:441.98
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References:Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);
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