CAS:183506-66-3|Apicidin

Catalogue Number:A726300
Chemical Name:Apicidin
Synonyms:Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-
CAS Number:183506-66-3
Molecular Formula:C₃₄H₄₉N₅O₆
Appearance:White to Off-White Solid
Melting Point:188-190ºC
Molecular Weight:623.78
Storage:4°C
Solubility:DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
Category:Research Tools; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.
References:Larsen, T., et al.: J. Microbiol. Methods, 24, 135 (1995), Bode, H., et al.: ChemBioChem., 3, 619 (2002), Nielsen, K., et al.: J. Agric. Food Chem., 53, 8190 (2005),
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