CAS:170729-80-3|Aprepitant

Catalogue Number:A729800
Chemical Name:Aprepitant
Synonyms:5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436;
CAS Number:170729-80-3
Molecular Formula:C₂₃H₂₁F₇N₄O₃
Appearance:White to Pale Beige Solid
Melting Point:242-250°C
Molecular Weight:534.43
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References:(1) Takemoto, H., et al.: nt J Clin Oncol (2016)
(2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016)
(3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)
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