CAS:1133387-60-6|Aprepitant-d4

Catalogue Number:A729803
Chemical Name:Aprepitant-d4
Synonyms:5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend-d4; L 754030-d4; MK 0869-d4; MK 869-d4; ONO 7436-d4;
CAS Number:1133387-60-6
Alternate CAS #
Unlabelled: 170729-80-3
Molecular Formula:C₂₃H₁₇D₄F₇N₄O₃
Appearance:White to Off-White Solid
Melting Point:242-244°C (subl.)
Molecular Weight:538.45
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly, Sonicated)
Category:Research Tools; Chiral Molecules; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.
References:Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)
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