3-Chloro-1-(4-nitrophenyl)piperidin-2-one

Chemical Name:3-Chloro-1-(4-nitrophenyl)piperidin-2-one
Synonyms:Apixaban impurity
Molecular Formula:C₁₁H₁₁ClN₂O₃
Molecular Weight:254.67
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3- Chloro-1-(4-nitrophenyl)piperidin-2-one is a useful synthesis intermediate. Apixaban (A726700) Impurity. Apixaban is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);
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