CAS:140158-50-5|(R,S)-ATPA

Catalogue Number:A790535
Chemical Name:(R,S)-ATPA
Synonyms:α-Amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-4-isoxazolepropanoic Acid;
CAS Number:140158-50-5
Molecular Formula:C₁₀H₁₆N₂O₄
Appearance:White to Off-White Solid
Melting Point:>231°C (dec.)
Molecular Weight:228.25
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.
References:(1) Procter, M. J., et al.: Neuropharmacology 37, 1287 (1998)
(2) Frydenvang, K., et al. Structural Chemistry 13, 479 (2002)
(3) Lv, Q., et al.: Brain Res 1456, 1 (2012)
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