CAS:173937-91-2|Atrasentan

Catalogue Number:A793925
Chemical Name:Atrasentan
Synonyms:Altrasentan; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic Acid; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; (+)-A 127722; A 147627; ABT 627;
CAS Number:173937-91-2
Alternate CAS #
HCl Salt: 195733-43-8
Molecular Formula:C₂₉H₃₈N₂O₆
Appearance:Off-White Solid
Melting Point:121-126ºC
Molecular Weight:510.62
Storage:-20°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
References:Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);
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