CAS:1035270-39-3|AZD4547

Catalogue Number:A808120
Chemical Name:AZD4547
Synonyms:rel-N-[5-b-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide; AZD-4547;
CAS Number:1035270-39-3
Molecular Formula:C₂₆H₃₃N₅O₃
Appearance:Pale Yellow to Light Beige Solid
Melting Point:168-170°C
Molecular Weight:463.57
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine kinases and is under clinical investigation for the treatment of FGFR-dependent tumors.
References:Gavine, P.R. et al.: Cancer Res., 72, 2045 (2012);
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