CAS:236750-62-2|2-Amino-4,5-bis(2-methoxyethoxy)benzamide

CAS:236750-62-2|2-Amino-4,5-bis(2-methoxyethoxy)benzamide

Catalogue Number:A898408
Chemical Name:2-Amino-4,5-bis(2-methoxyethoxy)benzamide
Synonyms:2-Amino-3,4-bis(2-methoxyethoxy)benzamide; 4,5-Bis(2-methoxyethoxy)anthranilamide; Erlotinib Impurity 19
CAS Number:236750-62-2
Molecular Formula:C₁₃H₂₀N₂O₅
Molecular Weight:284.31
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Amino-4,5-bis(2-methoxyethoxy)benzamide is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.
References:Li, Feng; Lu., et al.: Organic Letters., 18, 2580 (2016); Zhu, B., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 4679 (2014); Yao, T., et al.: Ther. Targets Neurol. Dis., 2, 585 (2015)
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