CAS:878385-84-3|AZD-5069

Catalogue Number:A965309
Chemical Name:AZD-5069
Synonyms:N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-1-azetidinesulfonamide; N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy]-4-pyrimidinyl]-1-azetidinesulfonamide; N-(2-((2,3-Difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
CAS Number:878385-84-3
Molecular Formula:C₁₈H₂₂F₂N₄O₅S₂
Appearance:White to Off-White Solid
Melting Point:149-152°C
Molecular Weight:476.52
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions.
References:De S., et al.: Eur. Respir. J., 46, 1021 (2015); Jurcevic, S., et al.: Br. J. Clin. Pharmacol., 80, 1324 (2015); Nicholls, D. J., et al.: J. Pharmacol. Exp. Ther., 353, 340 (2015)
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