CAS:1352226-88-0|AZD6738

Catalogue Number:A965423
Chemical Name:AZD6738
Synonyms:4-[4-[1-[[S(R)]-S-Methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine; AZD 6738
CAS Number:1352226-88-0
Molecular Formula:C₂₀H₂₄N₆O₂S
Appearance:Pale Yellow Solid
Molecular Weight:412.51
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:AZD6738 is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. In addition, AZD6738 sensitizes tumor cells to chemo- and radiotherapy. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival
References:Karnitz, Larry M., et al.: Clin Cancer Res., 21, 4780 (2015); Kwok, Marwan., et al.: Blood., 127, 582 (2016)
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