3-Desmethyl Trimethoprim-d3

Chemical Name:3-Desmethyl Trimethoprim-d3
Synonyms:2,4-Diamino-5-(3-hydroxy-4,5-dimethoxybenzyl-d3)pyrimidine
Alternate CAS #:27653-69-6
Molecular Formula:C₁₃H₁₃D₃N₄O₃
Molecular Weight:279.31
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Desmethyl Trimethoprim-d3 is a labelled metabolite of Trimethoprim (T795615); an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections. 3-Desmethyl Trimethoprim gets excreted in the urine of rats, dogs, and man in the form of glucuronides.
References:Roth, B., et al.: J. Med. Chem., 24, 933 (1981); Liu, Z., et al.: Biomed. Chromatogr., 26, 1101 (2012); Schwartz, D. E., Arzneimittel-Forsch., 20, 1867 (1970)
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