CAS:218600-44-3|Bardoxolone

Catalogue Number:B118660
Chemical Name:Bardoxolone
Synonyms:CDDO; RTA 401; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;
CAS Number:218600-44-3
Molecular Formula:C₃₁H₄₁NO₄
Appearance:Off-White to Light Brown Solid
Melting Point:>280ºC (dec.)
Molecular Weight:491.66
Storage:-20°C
Solubility:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
References:Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);
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