CAS:443776-49-6|BC 11 Hydrobromide

Catalogue Number:B129348
Chemical Name:BC 11 Hydrobromide
Synonyms:Carbamimidothioic Acid (4-Boronophenyl)methyl Ester Hydrobromide
CAS Number:443776-49-6
Alternate CAS #
Free Base: 770703-09-8
Molecular Formula:C₈H₁₁BN₂O₂S • HBr
Appearance:White to Off-White Solid
Melting Point:177 – 182°C
Molecular Weight:210.06 + 80.91
Storage:4°C, Hygroscopic
Solubility:Aqueous Base (Slightly), DMSO (Slightly), Water (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors;
Applications:BC 11 Hydrobromide, is a selective urokinase (uPA) inhibitor. It inhibits clot lysis without haveing any effect on clot formation. It has also shown to be able to decrease viability of MDA-MB231 breast cancer cells in vitro.
References:Smith, et al.: Int.Soc.Thromb.Haemost. (Abstract) 9 819 (2011); Longo et al.: Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 (2015);
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