Des-Phenol Tenofovir Alfenamide Dimer

Chemical Name:Des-Phenol Tenofovir Alfenamide Dimer
Synonyms:N-(1-Isopropoxy-1-oxopropan-2-yl)-P-((((2S)-1-(6-((((9-(2-((((1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonamidic Acid
Molecular Formula:C₃₇H₅₄N₁₂O₁₀P₂
Molecular Weight:888.85
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Des-Phenol Tenofovir Alfenamide Dimer is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References:Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);
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