L-Dicentrine-d3

Chemical Name:L-Dicentrine-d3
Synonyms:(7aR)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline-d3; 9,10-Dimethoxy-1,2-(methylenedioxy)-6aβ-aporphine-d3; (R)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline-d3; (-)-Dicentrine-d3; (R)-(-)-Dicentrine-d3; NSC 251699-d3;
Alternate CAS #:Unlabelled: 28832-07-7
Molecular Formula:C₂₀H₁₈D₃NO₄
Molecular Weight:342.4
Category:Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Labelled L-Dicentrine a natural vascular alpha 1-adrenoceptor antagonist but less prevalent than the D-isomer. It markedly inhibits the contraction of rat stomach muscle strips induced by 5-HT, histamine, K+ and Ca2+ after high K+ depolarization, showing a non-competitive antagonism and could be a potential muscle relaxant. Studies suggest that it has protective effect of on acute myocardial Iichemia and anoxia lesion.
References:Li, H. et al.: Zhong. Zhon. Zaz., 25, 426 (2000); Li, M. et al.: Acad. J. Kun. Med. Coll., 1003 (1997); Teng, C.M. et al.: Brit, J. Pharmacol., 104, 651 (1991);
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