CAS:32375-14-7|4′,7-Bis(benzyloxy)-5-hydroxy-flavone

Catalogue Number:B404975
Chemical Name:4′,7-Bis(benzyloxy)-5-hydroxy-flavone
Synonyms:5-​Hydroxy-​7-​(phenylmethoxy)​-​2-​[4-​(phenylmethoxy)​phenyl]​-4H-​1-​benzopyran-​4-​one; 7-(Benzyloxy)-2-(4-(benzyloxy)phenyl)-5-hydroxy-4H-chromen-4-one
CAS Number:32375-14-7
Molecular Formula:C₂₉H₂₂O₅
Appearance:Tan Solid
Molecular Weight:450.48
Solubility:DMF (Slightly), DMSO (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4′,7-Bis(benzyloxy)-5-hydroxy-flavone is an intermediate in synthesizing Apigenin 5-O-b-D-Glucuronide (A426510), a metabolite of Apigenin (A726500), Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap junction intracellular communication in liver cells.
References:Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994; Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994); Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)
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