(R)-2-((S)-1-((1R,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-2-((1S,3R,5S)-3-isocyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)succinic Acid

Chemical Name:(R)-2-((S)-1-((1R,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-2-((1S,3R,5S)-3-isocyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)succinic Acid
Synonyms:Saxagliptin Impurity 5
Molecular Formula:C₂₂H₂₈N₂O₆
Molecular Weight:416.47
Category:Standards; Chiral Molecules; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-2-((S)-1-((1R,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-((1S,3R,5S)-3-isocyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)succinic Acid is an impurity of Saxagliptin (S143500). Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes.
References:Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008);
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