2-Hydroxyglutarate-13C5,d8

Chemical Name:2-Hydroxyglutarate-13C5,d8
Alternate CAS #:2889-31-8 unlabelled
Molecular Formula:¹³C₅D₈O₅
Molecular Weight:161.13
Category:Research Tools; Isotopic Labeled Analogues; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:2-Hydroxyglutarate-13C5,d8 is the labelled analogue of 2-Hydroxyglutarate (2889-31-8), a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine (5mC) hydroxylases.
References:Xu, W., et al.: Cancer Cell, 19, 17 (2011)
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