Ketoconazole-N-methylformamide

Chemical Name:Ketoconazole-N-methylformamide
Synonyms:N-[[(2R,4S)-4-[[4-(4-Acetyl-1-piperazinyl)phenoxy]methyl]-2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl]methyl]-2-(formylamino)-acetamide
CAS Number:1253852-44-6
Molecular Formula:C₂₆H₃₀Cl₂N₄O₆
Molecular Weight:565.45
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Ketoconazole-N-methylformamide is a metabolite of Ketoconazole (K186000). Ketoconazole is an orally active 5-lipoxygenase and thromboxane synthase inhibitor. Also an Inhibitor of exosome secretion.
References:Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986); Scientific Reports 8: 8161 (2018)
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