1-[4-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)uracil

Chemical Name:1-[4-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)uracil
Synonyms:1-[4-C-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione
CAS Number:1333126-30-9
Molecular Formula:C₂₃H₁₇ClFN₅O₇
Molecular Weight:529.86
Category:Standards; Nucleic Acids; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications:1-[4-Azido-3-O-benzoyl-5-O-(3-chlorobenzoyl)-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil is reported to be a reactant used for the preparation of 2′-deoxy-2′-fluoro-4′-azido nucleoside analogs which exhibited extremely potent anti-HIV activity against NL4-3 (wild-type), NL4-3 (K101E), and RTMDR viral strains. Also it is used for the synthesis of 4-substituted fluoronucleoside analogs for the treatment of Hepatitis B virus infection.
References:Wang, Q., et al.:Eur. J. Med. Chem.,46,4178(2011); Yang, Q., et al.:J. Med. Chem.,58,3693(2015)
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