(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester

Chemical Name:(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester
Synonyms:tert-Butyl rel-(1R,5S,6S)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate; exo-N-Boc-6-amino-3-azabucyclo[3.1.0]hexane;
CAS Number:273206-92-1
Molecular Formula:C₁₀H₁₈N₂O₂
Molecular Weight:198.26
Category:Building Blocks; Miscellaneous;
Applications:(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester, is an intermediate in the preparation of a novel series of Histone Deacetylase (HDAC) Inhibitors, demonstrating class I selectivity and good oral bioavailability. It can also be used in the synthesis of Alatrofloxacin Mesylate (A511400).
References:Moffat, D., et al.: J. Med Chem., 53, 8663 (2010); Gladue, R., et al.: Antimicrob. Agent Chemother., 34, 1056 (1990); Bailly, S., et al.: Clin. Exp. Immunol., 85, 331 (1991);
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