3-Amino-4-(1,1-dimethylethyl)-6-[1,1-di(methyl-d3)ethyl-2,2,2-d3]phen-2-d-ol

Chemical Name:3-Amino-4-(1,1-dimethylethyl)-6-[1,1-di(methyl-d3)ethyl-2,2,2-d3]phen-2-d-ol
CAS Number:1577233-53-4
Molecular Formula:C₁₄H₁₃D₁₀NO
Molecular Weight:231.4
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Amino-4-(1,1-dimethylethyl)-6-[1,1-di(methyl-d3)ethyl-2,2,2-d3]phen-2-d-ol is an intermediate used in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603), which is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis.
References:Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);
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