Hydroxy Tacrine-d4

Chemical Name:Hydroxy Tacrine-d4
Synonyms:9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d4; 9-Amino-1,2,3,4-tetrahydro-1-acridinol-d3; HP 029-d3; Mentane-d3; P 83-6029A-d3; Velnacrine-d3;
CAS Number:1246911-78-3
Molecular Formula:C₁₃H₁₀D₄N₂O
Molecular Weight:218.29
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Hydroxy Tacrine-d4, is the labeled analogue of Hydroxy Tacrine (A629900), a potential Alzheimer’s Disease therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to THA except that it is far less toxic and without measurable liver toxicity in humans.
References:Alon, R., et al.: J. Cell Biol., 128, 1243 (1995), Min, W., et al.: J .Immunol., 159, 3508 (1997), Lum, A., et al.: J. Biol. Chem., 277, 20660 (2002), Carvalho, F., et al.: J. Appl. Toxicol., 24, 419 (2004),
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