AP 26113

Chemical Name:AP 26113
Synonyms:5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dimethylphosphinyl)phenyl]-2,4-pyrimidinediamine
CAS Number:1197958-12-5
Alternate CAS #:1350848-43-9 unspecified
Molecular Formula:C₂₆H₃₄ClN₆O₂P
Molecular Weight:529.01
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AP 26113 is a potent anaplastic lymphoma kinase (ALK) inhibitor. It is also an epidermal growth factor (EGFR) receptor tyrosine kinase inhibitor used for treatment of lung cancer.
References:Yu, H.A. et al.: J. Natio. Comp. Canc. Net., 11, 161 (2013)
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