Apigenin-d5 7-Glucuronide

Chemical Name:Apigenin-d5 7-Glucuronide
Synonyms:β-D-5-Hydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl-glucopyranosiduronic Acid-d5; Apigenin-d5 7-O-Glucuronide; Apigenin-d5 7-O-β-D-Glucuronide; Apigenin-d5 7-O-β-D-Glucuronopyranoside; Apigenin-d5 7-O-β-Glucuronide; Apigenin-d5 7-Glucuronide; Apigenin-d5 7-β-Glucuronide; Apigenin-d5-7-O-β-D Glucuronoside; Scutellarin A-d5
Alternate CAS #:29741-09-1 unlabelled
Molecular Formula:C₂₁H₁₃D₅O₁₁
Appearance:No data available
Melting Point:No data available
Molecular Weight:451.39
Solubility:No data available
Category:Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors;
Applications:Apigenin-d5 7-Glucuronide is labelled Apigenin 7-Glucuronide (A726505), a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap junction intracellular communication in liver cells.
References:Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)
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