Avosentan-d3

Chemical Name:Avosentan-d3
Synonyms:N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide-d3; Ro 67-0565-d3; SPP 301-d3;
CAS Number:1206674-82-9
Alternate CAS #:unlabelled: 290815-26-8
Molecular Formula:C₂₃H₁₈D₃N₅O₅S
Molecular Weight:482.53
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:Labelled Avosentan, a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.
References:Dieterle, W. et al.: J. Clin. Pharmacol., 44, 59 (2004); Dieterle, W. et al.: Int. J. Clin. Pharmacol. Ther., 43, 178 (2005); Wang, R.-F. et al.: Curr. Eye Res., 36, 41 (2011);
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