2-((((((S)-1-(2-Ethylbutoxy)-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-hydroxy Remdesivir

Chemical Name:2-((((((S)-1-(2-Ethylbutoxy)-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-hydroxy Remdesivir
Synonyms:Bis Phosphoryl impurity;(2R,3R,4R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxytetrahydrofuran-2-carbonitrile-bis-((2S)-2-ethylbutyl-2-((hydroxy(phenoxy)phosphoryl)amino)propanoate);(2S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-2-((((((S)-1-(2-ethylbutoxy)-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-hydroxytetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
Molecular Formula:C₄₂H₅₇N₇O₁₂P₂
Molecular Weight:913.89
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications:(2R,3R,4R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxytetrahydrofuran-2-carbonitrile-bis-((2S)-2-ethylbutyl-2-((hydroxy(phenoxy)phosphoryl)amino)propanoate) is a derivative of (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (A606090), which is a predominant metabolite of Remdesivir (CAS# 1809249-37-3) with great potential for Covid-19 treatment and N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine (N489600), which is used for the treatment of ebola and emerging viruses.
References:Yan, V. C., et al.: ACS Med. Chem., 11, 1361 (2020); Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)
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