Ethyl 5-Methyl-1H-1,2,4-triazole-3-carboxylate

Chemical Name:Ethyl 5-Methyl-1H-1,2,4-triazole-3-carboxylate
Synonyms:3-methyl-1H-1,2,4-Triazole-5-carboxylic acid ethyl ester; 5-methyl-1H-1,2,4-Triazole-3-carboxylic acid ethyl ester;
CAS Number:40253-47-2
Molecular Formula:C₆H₉N₃O₂
Molecular Weight:155.15
Category:Building Blocks; Miscellaneous;
Applications:Ethyl 5-Methyl-1H-1,2,4-triazole-3-carboxylateis used as a reagent in the synthesis of low- molecular derivatives of 1,2,4-triazole. It is also used as a reagent in the preparation of heterocyclic modulators of HIF activity which is used in treatment of cancer and other hypoxia mediated diseases.
References:Chudinov, M., et al.: Vestn. MITKHT, 6, 66 (2011); Jones, P., et al.: Preparation of heterocyclic modulators of HIF activity for the treatment of cancer and other hypoxia-mediated diseases, WO Patent 2014031936, Feb 27, 2014;
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