(Z)-Ethyl 3-(4-Benzylphenyl)-2-cyanobut-2-enoate

Chemical Name:(Z)-Ethyl 3-(4-Benzylphenyl)-2-cyanobut-2-enoate
Molecular Formula:C₂₀H₁₉NO₂
Molecular Weight:305.37
Category:Building Blocks; Miscellaneous;
Applications:(Z)-Ethyl 3-(4-Benzylphenyl)-2-cyanobut-2-enoate is an intermediate in synthesizing Barbadin (B118250), a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.
References:Beautrait, A., et al.: Nat Commun. 8, 15054 (2017)
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