1-​[(2-​Fluorophenyl)​methyl]​-​1H-1,2,3-triazole-4-carboxylic Acid Methyl Ester

Chemical Name:1-​[(2-​Fluorophenyl)​methyl]​-​1H-1,2,3-triazole-4-carboxylic Acid Methyl Ester
Synonyms:Methyl 1-(2-Fluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
CAS Number:1205975-58-1
Molecular Formula:C₁₁H₁₀FN₃O₂
Molecular Weight:235.21
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-​[(2-​Fluorophenyl)​methyl]​-​1H-1,2,3-triazole-4-carboxylic Acid Methyl Ester is an intermediate in the synthesis of 6-Desfluoro Rufinamide (D290315), which is an impurity in the synthesis of Rufinamide (R701550), an antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant.
References:Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),
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