N-formyl Ribociclib

Chemical Name:N-formyl Ribociclib
Synonyms:7-cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Ribociclib impurity
Molecular Formula:C₂₄H₃₀N₈O₂
Molecular Weight:462.55
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-Formylpiperazin-1-yl LEE 011 is an impurity of LEE 011 which can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
References:Jansen, V. M., et al.: Cancer Research, 77, 2488 (2017)
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