2-​Hydroxy Cabozantinib

Chemical Name:2-​Hydroxy Cabozantinib
Synonyms:N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N’-(4-fluoro-2-hydroxyphenyl)-1,1-cyclopropanedicarboxamide; N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
CAS Number:1628530-38-0
Alternate CAS #:849217-68-1
Molecular Formula:C₂₈H₂₄FN₃O₆
Molecular Weight:517.51
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-​Hydroxy Cabozantinib is a metabolite of cabozantinib (CAS# 849217-68-1), which is a tyrosine kinase inhibitor and an anticancer drug used in the treatment of thyroid cancer, renal cell carcinoma and hepatocellular carcinoma.
References:Aftab, D. T., et al.: PCT Int. Appl., 65pp. (2014); Viola, D., et al.: Future Oncol., 9, 1083 (2013); Sherman, S. I., et al.: Cancer (Hoboken, NJ, U. S.), 122, 3856 (2016); Wiecek, W., et al.: PLoS One, 11, 0155389/1 (2016); Chuma, M., et al.: Hepatol. Res., 45, E1 (2015)
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